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Notice of Proposed Sale · 144

Spyre Therapeutics, Inc.

SYRENASDAQEQUITYCurrent

Notice of Proposed Sale

Filed Oct 1, 2026Accepted Oct 1, 2026, 4:30 PM EDTFiling CIK 1794898Accession 0001950047-26-009971
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Structured filing — 144

primary_doc.xml

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Notice of proposed sale. The proposed amounts below do not establish that a sale occurred.

Proposed-sale notice

Issuer
SPYRE THERAPEUTICS, INC.
Issuer CIK
0001636282
SEC file number
001-37722
Phone
6176515940
Person for whose account securities are to be sold
HEIDY KING-JONES
Relationships to issuer
Officer
Street
221 Crescent Street Building 23
Street (continued)
Suite 105
City
Waltham
State / country code
MA
Postal code
02453

Securities proposed for sale

Securities proposed for sale · 1 reported row
SecurityProposed unitsAggregate market valueUnits outstandingApproximate sale dateExchangeBroker / market maker
Common29,3352,611,695.0588,173,76210/01/2026NASDAQMorgan Stanley Smith Barney LLC Executive Financial Services

Broker / market maker — proposed row 1, entry 1

Name
Morgan Stanley Smith Barney LLC Executive Financial Services
Street
1 New York Plaza
Street (continued)
8th Floor
City
New York
State / country code
NY
Postal code
10004

Acquisition of securities to be sold

Acquisition of securities to be sold · 1 reported row
SecurityAcquiredNature of acquisitionAcquired fromAmount acquiredGift transactionPayment dateNature of payment
Common10/01/2026Exercise of Stock OptionsIssuer29,335N10/01/2026Cash

Sales reported in the preceding three months

Sales reported in the preceding three months · 2 reported rows
SellerSecuritySale dateAmount soldGross proceeds
10b5-1 Sales for HEIDY M KING-JONESCommon09/02/202640036,000.00
10b5-1 Sales for HEIDY M KING-JONESCommon09/01/202627,9992,444,477.89

Seller — prior-sale row 1, entry 1

Name
10b5-1 Sales for HEIDY M KING-JONES
Street
221 Crescent Street Building 23
Street (continued)
Suite 105
City
Waltham
State / country code
MA
Postal code
02453

Seller — prior-sale row 2, entry 1

Name
10b5-1 Sales for HEIDY M KING-JONES
Street
221 Crescent Street Building 23
Street (continued)
Suite 105
City
Waltham
State / country code
MA
Postal code
02453

Prior-sale reporting

Nothing to report for the preceding three months
N

Remarks

The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.

Notice signature

Notice date
10/01/2026
Signed
/s/ Heidy King-Jones
Plan adoption dates
04/16/2026

Company context

Current securities

Historical securities (1)

Recent company filings

  1. Regulation FD Disclosure · Other EventsSep 8, 2026
  2. 144 filingSep 1, 2026
  3. Regulation FD Disclosure · Other EventsAug 25, 2026
  4. 144 filingAug 7, 2026
  5. 144 filingAug 7, 2026

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