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Notice of Proposed Sale · 144

Maze Therapeutics, Inc.

MAZENASDAQEQUITYCurrent

Notice of Proposed Sale

Filed Oct 1, 2026Accepted Oct 1, 2026, 4:02 PM EDTFiling CIK 1842295Accession 0001969223-26-001044
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Structured filing — 144

primary_doc.xml

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Notice of proposed sale. The proposed amounts below do not establish that a sale occurred.

Proposed-sale notice

Issuer
Maze Therapeutics, Inc.
Issuer CIK
0001842295
SEC file number
001-42490
Phone
6508505070
Person for whose account securities are to be sold
Coloma Jason V
Relationships to issuer
Officer
Street
171 OYSTER POINT BOULEVARD, SUITE 300
City
SOUTH SAN FRANCISCO
State / country code
CA
Postal code
94080

Securities proposed for sale

Securities proposed for sale · 1 reported row
SecurityProposed unitsAggregate market valueUnits outstandingApproximate sale dateExchangeBroker / market maker
Common34,501933,252.0555,549,16810/01/2026NasdaqUBS Financial Services Inc.

Broker / market maker — proposed row 1, entry 1

Name
UBS Financial Services Inc.
Street
Eleven Madison Avenue
Street (continued)
4th Floor
City
New York
State / country code
NY
Postal code
10010

Acquisition of securities to be sold

Acquisition of securities to be sold · 2 reported rows
SecurityAcquiredNature of acquisitionAcquired fromAmount acquiredGift transactionDonor acquiredPayment dateNature of payment
Common09/22/2021GiftJason Coloma2,593Y11/01/201809/22/2021NA
Common09/22/2021GiftJason Coloma31,908Y06/24/201909/22/2021NA

Sales reported in the preceding three months

Sales reported in the preceding three months · 6 reported rows
SellerSecuritySale dateAmount soldGross proceeds
The Coloma 2021 Irrevocable Trust DTD 09/20/2021Common08/03/20262,59369,329.00
The Coloma 2021 Irrevocable Trust DTD 09/20/2021Common07/01/20262,59377,726.21
Coloma Family Trust DTD 06/27/2016Common08/03/202631,908852,983.80
Coloma Family Trust DTD 06/27/2016Common07/01/202631,908956,528.45
The Coloma 2021 Irrevocable Trust DTD 09/20/2021Common09/01/20262,59368,214.05
Coloma Family Trust DTD 06/27/2016Common09/01/202631,908838,784.74

Seller — prior-sale row 1, entry 1

Name
The Coloma 2021 Irrevocable Trust DTD 09/20/2021
Street
171 OYSTER POINT BOULEVARD, SUITE 300
City
SOUTH SAN FRANCISCO
State / country code
CA
Postal code
94080

Seller — prior-sale row 2, entry 1

Name
The Coloma 2021 Irrevocable Trust DTD 09/20/2021
Street
171 OYSTER POINT BOULEVARD, SUITE 300
City
SOUTH SAN FRANCISCO
State / country code
CA
Postal code
94080

Seller — prior-sale row 3, entry 1

Name
Coloma Family Trust DTD 06/27/2016
Street
171 OYSTER POINT BOULEVARD, SUITE 300
City
SOUTH SAN FRANCISCO
State / country code
CA
Postal code
94080

Seller — prior-sale row 4, entry 1

Name
Coloma Family Trust DTD 06/27/2016
Street
171 OYSTER POINT BOULEVARD, SUITE 300
City
SOUTH SAN FRANCISCO
State / country code
CA
Postal code
94080

Seller — prior-sale row 5, entry 1

Name
The Coloma 2021 Irrevocable Trust DTD 09/20/2021
Street
171 OYSTER POINT BOULEVARD
Street (continued)
Suite 300
City
SOUTH SAN FRANCISCO
State / country code
CA
Postal code
94080

Seller — prior-sale row 6, entry 1

Name
Coloma Family Trust DTD 06/27/2016
Street
171 OYSTER POINT BOULEVARD
Street (continued)
SUITE 300
City
SOUTH SAN FRANCISCO
State / country code
CA
Postal code
94080

Prior-sale reporting

Nothing to report for the preceding three months
N

Remarks

2,593 shares for this filing were sold under The Coloma 2021 Irrevocable Trust DTD 09/20/2021 and 31,908 shares were sold under Coloma Family Trust DTD 06/27/2016

Notice signature

Notice date
10/01/2026
Signed
/s/ UBS Financial Services Inc., as attorney-in-fact for Jason Coloma as trustee
Plan adoption dates
02/06/2026

Company context

Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing the power of human genetics to develop novel small molecule precision medicines for patients with kidney and metabolic diseases. Guided by its Compass™ platform, Maze pursues genetically validated targets by integrating variant discovery and functionalization to discover and advance small molecule programs with first- or best-in-class potential. Maze’s pipeline is led by MZE829, a dual-mechanism APOL1 inhibitor in Phase 2 development for APOL1-mediated kidney disease (AMKD), and MZE782, a SLC6A19 inhibitor in Phase 2 development with the potential to treat both phenylketonuria (PKU) and chronic kidney disease (CKD). Maze is headquartered in South San Francisco. For more information, please visit mazetx.com, or follow Maze on LinkedIn and X.

Current securities

Recent company filings

  1. 4 filingOct 2, 2026
  2. 4 filingSep 4, 2026
  3. 4 filingSep 3, 2026
  4. 3 filingAug 17, 2026
  5. Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements · Regulation FD DisclosureAug 17, 2026

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