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Changes in Beneficial Ownership · 4

Maze Therapeutics, Inc.

MAZENASDAQEQUITYCurrent

Changes in Beneficial Ownership

Filed Oct 2, 2026Accepted Oct 2, 2026, 4:12 PM EDTFiling CIK 1842295Accession 0001676170-26-000024
Share

Structured filing — 4

form4-10022026_081010.xml

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Filing details

Report period
2026-10-01
Issuer
Maze Therapeutics, Inc.
Issuer CIK
0001842295
Trading symbol
MAZE
Rule 10b5-1 indication
Checked

Reporting owner 1

Name
Coloma Jason V
Reporting owner CIK
0001676170
Relationship
Director · Officer
Officer title
Chief Executive Officer
Address
C/O MAZE THERAPEUTICS, INC., 171 OYSTER POINT BOULEVARD, SUITE 300, SOUTH SAN FRANCISCO, CA, 94080

Non-derivative transactions

Non-derivative transactions · 2 reported rows
SecurityTransaction dateCodeAmountA / DPrice (USD)Owned afterOwnershipNature of ownership
Common Stock2026-10-01S · Form 4[F1]2,593D27.0241[F2]15,558IThe Coloma 2021 Irrevocable Trust[F3]
Common Stock2026-10-01S · Form 4[F1]31,908D27.0210[F4]191,447IColoma Family Trust[F5]
Table key
S · Form 4
Sale on the market or privately
D
Disposed
I
Indirect

Non-derivative holdings

Non-derivative holdings · 1 reported row
SecurityAmount ownedOwnership
Common Stock27,362D
Table key
D
Direct

Footnotes

F1
This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 6, 2026.↩ 1↩ 2
F2
The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.645 to $27.46 per share, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote and in footnote 4 of this Form 4.↩ 1
F3
These securities are directly held by The Coloma 2021 Irrevocable Trust, for which the reporting person and his spouse serve as co-trustees.↩ 1
F4
The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.585 to $27.47 per share, inclusive.↩ 1
F5
These securities are directly held by the Coloma Family Trust, for which the reporting person and his spouse serve as co-trustees.↩ 1

Signature 1

Signed
/s/ Courtney Phillips, as attorney-in-fact
Date
2026-10-02

Company context

Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing the power of human genetics to develop novel small molecule precision medicines for patients with kidney and metabolic diseases. Guided by its Compass™ platform, Maze pursues genetically validated targets by integrating variant discovery and functionalization to discover and advance small molecule programs with first- or best-in-class potential. Maze’s pipeline is led by MZE829, a dual-mechanism APOL1 inhibitor in Phase 2 development for APOL1-mediated kidney disease (AMKD), and MZE782, a SLC6A19 inhibitor in Phase 2 development with the potential to treat both phenylketonuria (PKU) and chronic kidney disease (CKD). Maze is headquartered in South San Francisco. For more information, please visit mazetx.com, or follow Maze on LinkedIn and X.

Current securities

Recent company filings

  1. 144 filingOct 1, 2026
  2. 4 filingSep 4, 2026
  3. 4 filingSep 3, 2026
  4. 3 filingAug 17, 2026
  5. Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements · Regulation FD DisclosureAug 17, 2026

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