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Notice of Proposed Sale · 144

Xeris Biopharma Holdings, Inc.

XERSNASDAQEQUITYCurrent

Notice of Proposed Sale

Filed Oct 1, 2026Accepted Oct 1, 2026, 4:26 PM EDTFiling CIK 1867096Accession 0001950047-26-009959

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Notice of proposed sale. The proposed amounts below do not establish that a sale occurred.

Proposed-sale notice

Issuer: XERIS BIOPHARMA HOLDINGS, INC.
Issuer CIK: 0001867096
SEC file number: 001-40880
Phone: 8444455704
Person for whose account securities are to be sold: BETH HECHT
Relationships to issuer: Officer
Street: 1375 West Fulton Street, Suite 1300
City: Chicago
State / country code: IL
Postal code: 60607

Securities proposed for sale

Securities proposed for sale · 1 reported row
Security	Proposed units	Aggregate market value	Units outstanding	Approximate sale date	Exchange	Broker / market maker
Common	16,666	159,326.96	182,320,306	10/01/2026	NASDAQ	Morgan Stanley Smith Barney LLC Executive Financial Services

Broker / market maker — proposed row 1, entry 1

Name: Morgan Stanley Smith Barney LLC Executive Financial Services
Street: 1 New York Plaza
Street (continued): 8th Floor
City: New York
State / country code: NY
Postal code: 10004

Acquisition of securities to be sold

Acquisition of securities to be sold · 2 reported rows
Security	Acquired	Nature of acquisition	Acquired from	Amount acquired	Gift transaction	Payment date	Nature of payment
Common	01/29/2023	Restricted Stock Units	Issuer	15,229	N	01/29/2023	N/A
Common	03/13/2020	Open Market Purchase	Issuer	1,437	N	03/13/2020	Cash

Sales reported in the preceding three months

Sales reported in the preceding three months · 2 reported rows
Seller	Security	Sale date	Amount sold	Gross proceeds
10b5-1 Sales for BETH HECHT	Common	09/01/2026	16,666	141,433.67
10b5-1 Sales for BETH HECHT	Common	08/03/2026	16,666	133,553.66

Seller — prior-sale row 1, entry 1

Name: 10b5-1 Sales for BETH HECHT
Street: 1375 West Fulton Street, Suite 1300
City: Chicago
State / country code: IL
Postal code: 60607

Seller — prior-sale row 2, entry 1

Name: 10b5-1 Sales for BETH HECHT
Street: 1375 West Fulton Street, Suite 1300
City: Chicago
State / country code: IL
Postal code: 60607

Prior-sale reporting

Nothing to report for the preceding three months: N

Notice signature

Notice date: 10/01/2026
Signed: /s/ Beth P. Hecht
Plan adoption dates: 08/08/2025

Company context

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