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BCS

Changes in Beneficial Ownership · 4

Cadrenal Therapeutics, Inc.

Changes in Beneficial Ownership

Filed Oct 13, 2026Accepted Oct 13, 2026, 5:33 PM EDTFiling CIK 1937993Accession 0001213900-26-109132
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Structured filing — 4

ownership.xml

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Filing details

Report period
2026-10-09
Issuer
Cadrenal Therapeutics, Inc.
Issuer CIK
0001937993
Trading symbol
CVKD

Reporting owner 1

Name
Pham Quang X
Reporting owner CIK
0001405290
Relationship
Director · Officer · 10% owner
Officer title
Chairman and CEO
Address
C/O CADRENAL THERAPEUTICS, INC., 822 A1A NORTH, SUITE 306, PONTE VEDRA, FL, 32082

Derivative transactions

Derivative transactions · 1 reported row
SecurityConversion / exercise price (USD)Transaction dateCodeAmountA / DPrice (USD)ExercisableExpiresUnderlying securityUnderlying sharesOwned afterOwnership
Stock Option0.912026-10-09A · Form 4200,000[F1]A02026-10-09[F1]2036-10-08Common Stock200,000200,000D
Table key
A · Form 4
Acquisition by grant, award or otherwise under Rule 16b-3(d)
A
Acquired
D
Direct

Footnotes

F1
The stock options have a grant date of October 9, 2026 under the Issuer's 2022 Successor Equity Incentive Plan, were fully vested and immediately exercisable on the date of grant, and have an exercise price equal to the closing price of the Issuer's common stock on October 9, 2026.↩ 1↩ 2

Signature 1

Signed
/s/ Quang X. Pham
Date
2026-10-13

Company context

Cadrenal Therapeutics, Inc. is a late-stage biopharmaceutical company advancing specialized therapies for critical care cardiology and orphan cardiovascular conditions. The Company’s pipeline includes CAD-1005, tecarfarin, and frunexian. CAD-1005 is a novel investigational therapeutic in development for the treatment of heparin-induced thrombocytopenia (HIT) and Cardiac Surgery-Associated Acute Kidney Injury (CSA-AKI). CAD-1005 is designed to selectively inhibit 12-lipoxygenase (12-LOX), an enzyme central to platelet immune activation and thrombo-inflammatory signaling in HIT. CAD-1005 is intended to be used alongside existing standards of care and is being developed to address the underlying biological mechanisms that drive disease progression. CAD-1005 has an Orphan Drug Designation (“ODD”) from the U.S. Food and Drug Administration (“FDA”) for prophylaxis of thrombosis in patients with HIT, FDA Fast Track designation for the treatment and prevention of HIT, and an orphan designation from the European Medicines Agency for the treatment of platelet-activating factor 4 disorders. Second-generation 12-LOX oral therapeutics (CAD-2000) are also in development for chronic indications.

Current securities

Recent company filings

  1. 4 filingOct 13, 2026
  2. 4 filingOct 13, 2026
  3. 4 filingOct 13, 2026
  4. 4 filingOct 13, 2026
  5. S-8 filingOct 8, 2026

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