Ordinary Shares, par value $0.135 per share
- Symbol
- SLXN
- Exchange
- NASDAQ
- Classification
- COMMON
- Status
- Current
Current Report · Items 7.01, 9.01 · 8-K
Silexion Therapeutics Corp
SLXNNASDAQEQUITYCurrent
Regulation FD Disclosure
Item 7.01 Regulation FD Disclosure. On August 10, 2026, Silexion Therapeutics Corp (the “Company”) published an updated corporate presentation titled “Silencing Oncogenes at the Level of Gene Expression” in which the Company included an updated timeline for the expected clinical testing and regulatory approval process for its SIL 204 lead product candidate.…
Company context
We are a clinical-stage biotechnology company developing, through our subsidiaries, RNA interference (RNAi) therapies for cancers driven by mutations in the Kirsten rat sarcoma viral oncogene homolog (“KRAS”). Our approach targets a significant unmet medical need, as treatment innovation for KRAS-driven cancers has historically lagged despite KRAS being one of the most common oncogenic drivers across solid tumors. In pancreatic cancer, for example, approximately 92% of patients have this mutated oncogene. While multiple pharmaceutical companies are pursuing strategies to inhibit KRAS and thereby limit its downstream signaling, our approach is differentiated by targeting the root cause of oncogenic signaling; our lead product candidate, SIL204, is a second-generation siRNA therapy that is engineered to suppress the KRAS oncogene itself, preventing the production of the oncogenic protein. We utilize an integrated treatment approach that combines administering SIL204 both directly into the tumor and systemically via subcutaneous injection, in combination with standard-of-care chemotherapy. In a previous Phase 2 clinical trial with our first-generation siRNA, the combination of siRNA and standard-of-care chemotherapy demonstrated an overall survival benefit compared to standard-of-care chemotherapy alone. Building on preclinical advancements and regimen optimization, we believe SIL204 has the potential to further improve clinical outcomes.
Current securities
Registered securities in this filing
Silexion Therapeutics Corp · 8-K · Filed 2026-08-10
Warrants exercisable for Ordinary Shares at an exercise price of $15,525.00 per share
- Symbol
- SLXNW
- Exchange
- NASDAQ
- Classification
- WARRANT
- Status
- Current
Disclosure sections
Item 7.01Item 7.01 - Regulation FD Disclosure
Item 7.01 Regulation FD Disclosure.
On August 10, 2026, Silexion Therapeutics Corp
(the “Company”) published an updated corporate presentation titled “Silencing Oncogenes at the Level of Gene
Expression” in which the Company included an updated timeline for the expected clinical testing and regulatory approval process
for its SIL 204 lead product candidate. A copy of the presentation is furnished as Exhibit 99.1 to this Current Report on Form 8-K (this
“Form 8-K”) and is incorporated herein by reference.
The information in Item 7.01 of this Form 8-K,
including the presentation furnished pursuant to this Item 7.01 of Form 8-K, shall not be deemed “filed” for the purposes
of Section 18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liabilities of that section. Furthermore,
the information in Item 7.01 of this Form 8-K, including the presentation, shall not be deemed to be incorporated by reference in the
filings of the registrant under the Securities Act of 1933, as amended.